A1 carriageway closed due to serious crash at Wetherby Services
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The carriageway is expected to be closed until at least 4pm on Friday - which could cause serious traffic delays.
North Yorkshire Police said officers are at the scene with a Collision Investigation Unit.
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Hide AdThe force has asked drivers to use alternative routes until further notice.
Traffic is now building in the area.
North Yorkshire Police said: "A1 Southbound closed at Wetherby Services due to serious collision.
"It is expected to be closed for the next hour and a half.
"Officers are at the scene along with the Collision Investigation Unit (CIU).
"Please use alternative routes until further notice. Updates to follow."